{"@context":"https://schema.org","@type":"NewsArticle","generatedAt":"2026-07-28T06:20:51.496Z","headline":"北大团队基于AlphaFold3接触概率开发ContactSeek框架，赋能精准碱基编辑","description":"北京大学生命科学学院伊成器课题组联合华东师大团队，在《自然》发表论文，提出基于AlphaFold3接触概率（CP）的AI框架ContactSeek。该框架整合AlphaFold3预测的CP与高通量脱靶编辑数据，系统识别Cas蛋白和脱氨酶中决定编辑特异性的关键氨基酸残基，并据此工程化改造碱基编辑工具。研究鉴定出一系列可提升ABE精准性的全新Cas9变体，在维持高效在靶编辑的同时降低DNA脱靶编辑。","url":"https://www.aioga.com/news/cmrzy9tm101zxrop1a26o2tng/","mainEntityOfPage":"https://www.aioga.com/news/cmrzy9tm101zxrop1a26o2tng/","datePublished":"2026-07-25T05:17:22.000Z","dateModified":"2026-07-25T05:17:22.000Z","inLanguage":"zh-CN","publisher":{"@type":"NewsMediaOrganization","name":"Aioga","url":"https://www.aioga.com"},"citation":["https://www.ithome.com/0/981/478.htm","https://aihot.virxact.com/items/cmrzy9tm101zxrop1a26o2tng"],"canonicalUrl":"https://www.aioga.com/news/cmrzy9tm101zxrop1a26o2tng/","directAnswer":{"@type":"Answer","text":"Aioga 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ContactSeek","summary":"北京大学生命科学学院伊成器课题组联合华东师大团队，在《自然》发表论文，提出基于AlphaFold3接触概率（CP）的AI框架ContactSeek。该框架整合AlphaFold3预测的CP与高通量脱靶编辑数据，系统识别Cas蛋白和脱氨酶中决定编辑特异性的关键氨基酸残基，并据此工程化改造碱基编辑工具。研究鉴定出一系列可提升ABE精准性的全新Cas9变体，在维持高效在靶编辑的同时降低DNA脱靶编辑。","source":"IT之家（RSS）","sourceUrl":"https://www.ithome.com/0/981/478.htm","aiHotUrl":"https://aihot.virxact.com/items/cmrzy9tm101zxrop1a26o2tng","publishedAt":"2026-07-25T05:17:22.000Z","category":"论文研究","score":36,"selected":false,"articleBody":["IT之家：https://www.ithome.com/ 7 月 25 日消息，北京大学生命科学学院发布博文，宣布其伊成器课题组于 7 月 22 日联合在《自然》（Nature）发表论文， 提出基于 AlphaFold3 接触概率的 AI 框架 ContactSeek。","该论文名为《Precise DNA base editing using AlphaFold3-based contact modelling》，由北京大学生命科学学院、基因功能研究与操控全国重点实验室、核糖核酸北京研究中心 伊成器 课题组与华东师范大学生命科学学院 李大力 课题组共同发表。","研究团队整合 AlphaFold3 预测的接触概率（contact probability，CP）与高通量测序获得的脱靶编辑信息，开发了 AI 驱动的 ContactSeek 框架。","AlphaFold3 是由谷歌旗下 DeepMind 推出的人工智能模型，主要用于预测蛋白质三维结构。更新版本还可分析蛋白质与核酸、以及多分子复合物的相互作用。","该框架系统识别 Cas 蛋白和脱氨酶中决定编辑特异性的关键氨基酸残基，并据此工程化改造碱基编辑工具，显著提升了编辑特异性，为实现基因编辑工具的精准性设计提供了新范式。","研究团队指出，碱基编辑器已是基础研究和疾病治疗的重要工具，但在保持高编辑活性的同时降低脱靶活性，一直是基因编辑领域的核心问题。","团队使用 AlphaFold3 预测在靶位点与脱靶位点的 DNA-RNA-蛋白质三元复合物，比较两类复合物的互作差异。","研究发现，AlphaFold3 生成的部分结构预测结果，未直接反映碱基错配带来的构象变化；但其输出的 contact probability，CP（接触概率）可灵敏捕捉变化。","CP 用于表示任意两个氨基酸或核苷酸残基处于邻近位置的可能性，数值可用于判断残基间是否存在相互作用。团队基准测试显示，CP 可反映单碱基对错配引发的局部构象变化，也可响应单个氨基酸突变带来的互作变化。","在此基础上，研究团队整合 CP 与高通量脱靶编辑数据，构建 ContactSeek（接触搜索）框架，解析脱靶复合物与在靶复合物的互作差异，并定位影响碱基编辑特异性的关键氨基酸位点。","基于这一框架，团队鉴定出一系列可提升 ABE（腺嘌呤碱基编辑器）精准性的全新 Cas9 变体，在维持高效在靶编辑的同时，降低 DNA 脱靶编辑。来源：北京大学生命科学学院。","Nature | 伊成器课题组与合作者建立基于 AlphaFold3 接触概率的人工智能框架，赋能精准碱基编辑：https://www.bio.pku.edu.cn/homes/Index/news_cont/22/18997.html","Precise DNA base editing using AlphaFold3-based contact 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将其归入「论文研究」方向，重点关注它对真实使用和行业竞争的影响。","background":"背景分析：模型与研究类动态需要结合能力边界、开放方式、成本、可用性和真实任务表现判断，单项指标领先不等于已经形成稳定采用。","viewpoint":"Aioga 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AI资讯","description":"北京大学生命科学学院伊成器课题组联合华东师大团队，在《自然》发表论文，提出基于AlphaFold3接触概率（CP）的AI框架ContactSeek。该框架整合AlphaFold3预测的CP与高通量脱靶编辑数据，系统识别Cas蛋白和脱氨酶中决定编辑特异性的关键氨基酸残基，并据此工程化改造碱基编辑工具。研究鉴定出一系列可提升ABE精准性的全新Cas9变体，在维持...","url":"https://www.aioga.com/news/cmrzy9tm101zxrop1a26o2tng/"},"en":{"title":"The Peking University team developed the ContactSeek framework based on AlphaFold3 contact probabilities, empowering precise base editing","summary":"The Yichengqi Research Group at the School of Life Sciences, Peking University, in collaboration with the East China Normal University team, published a paper in Nature, proposing an AI framework called ContactSeek based on AlphaFold3 contact probability (CP). This framework integrates CP predicted by AlphaFold3 with high-throughput off-target editing data to systematically identify key amino acid residues in Cas proteins and deaminases that determine editing specificity, and uses this information to engineer base editing tools. The study identified a series of new Cas9 variants that can improve the precision of ABEs, maintaining efficient on-target editing while reducing DNA off-target edits.","category":"Research","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"The Peking University team developed the ContactSeek framework based on AlphaFold3 contact probabilities, empowering precise base editing - Aioga AI News","description":"The Yichengqi Research Group at the School of Life Sciences, Peking University, in collaboration with the East China Normal University team, published a paper in Nature, proposing...","url":"https://www.aioga.com/en/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:42:29.017Z"},"ja":{"title":"北大チームはAlphaFold3に基づく接触確率を用いてContactSeekフレームワークを開発し、精密な塩基編集を可能にする","summary":"北京大学生命科学学院の伊成器研究室は華東師範大学のチームと共同で、『ネイチャー』に論文を発表し、AlphaFold3の接触確率（CP）に基づくAIフレームワークContactSeekを提案しました。このフレームワークは、AlphaFold3で予測されたCPと高スループットのオフターゲット編集データを統合し、Casタンパク質と脱アミノ酶における編集特異性を決定する重要なアミノ酸残基を体系的に特定し、それに基づいて塩基編集ツールをエンジニアリング改変します。研究により、一連のABEの精度を向上させる新規Cas9変異体が同定され、高効率なオンターゲット編集を維持しながらDNAのオフターゲット編集を低減することが可能となりました。","category":"論文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"北大チームはAlphaFold3に基づく接触確率を用いてContactSeekフレームワークを開発し、精密な塩基編集を可能にする - Aioga AIニュース","description":"北京大学生命科学学院の伊成器研究室は華東師範大学のチームと共同で、『ネイチャー』に論文を発表し、AlphaFold3の接触確率（CP）に基づくAIフレームワークContactSeekを提案しました。このフレームワークは、AlphaFold3で予測されたCPと高スループットのオフターゲット編集データを統合し、Casタンパク質と脱アミノ酶における編集特異性を決定...","url":"https://www.aioga.com/ja/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:42:40.025Z"},"ko":{"title":"북대 팀은 AlphaFold3 접촉 확률을 기반으로 ContactSeek 프레임워크를 개발하여 정밀 염기 편집을 지원합니다","summary":"베이징대학교 생명과학원 이성기 연구팀은 화동사범대 팀과 공동으로 《네이처》에 논문을 발표하고, AlphaFold3 접촉 확률(CP)에 기반한 AI 프레임워크 ContactSeek를 제안했다. 이 프레임워크는 AlphaFold3가 예측한 CP와 고속 탈표적 편집 데이터를 통합하여 Cas 단백질과 탈아민화효소에서 편집 특이성을 결정하는 핵심 아미노산 잔기를 체계적으로 식별하고, 이를 바탕으로 염기 편집 도구를 공학적으로 개조한다. 연구는 높은 타깃 편집 효율을 유지하면서 DNA 비표적 편집을 낮추는 ABE 정확성을 향상시킬 수 있는 새로운 Cas9 변체들을 일련으로 확인했다.","category":"연구","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"북대 팀은 AlphaFold3 접촉 확률을 기반으로 ContactSeek 프레임워크를 개발하여 정밀 염기 편집을 지원합니다 - Aioga AI 뉴스","description":"베이징대학교 생명과학원 이성기 연구팀은 화동사범대 팀과 공동으로 《네이처》에 논문을 발표하고, AlphaFold3 접촉 확률(CP)에 기반한 AI 프레임워크 ContactSeek를 제안했다. 이 프레임워크는 AlphaFold3가 예측한 CP와 고속 탈표적 편집 데이터를 통합하여 Cas 단백질과 탈아민화효소에서 편집 특이성...","url":"https://www.aioga.com/ko/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:43:29.795Z"},"es":{"title":"El equipo de la Universidad de Pekín desarrolló el marco ContactSeek basado en la probabilidad de contacto de AlphaFold3, potenciando la edición precisa de bases","summary":"El grupo de investigación de Yi Chengqi de la Facultad de Ciencias Biológicas de la Universidad de Pekín, en colaboración con el equipo de la Universidad Normal del Este de China, publicó un artículo en 'Nature', proponiendo el marco de IA ContactSeek basado en la probabilidad de contacto (CP) de AlphaFold3. Este marco integra la CP predicha por AlphaFold3 con datos de edición fuera del objetivo de alta capacidad, identificando de manera sistemática los residuos de aminoácidos clave que determinan la especificidad de la edición en proteínas Cas y desaminasas, y con base en ello, realiza ingeniería para modificar herramientas de edición de bases. El estudio identificó una serie de nuevas variantes de Cas9 que pueden mejorar la precisión de ABE, manteniendo una edición eficiente en el objetivo mientras se reduce la edición fuera del objetivo en el ADN.","category":"Investigación","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"El equipo de la Universidad de Pekín desarrolló el marco ContactSeek basado en la probabilidad de contacto de AlphaFold3, potenciando la edición precisa de bases - Aioga Noticias de IA","description":"El grupo de investigación de Yi Chengqi de la Facultad de Ciencias Biológicas de la Universidad de Pekín, en colaboración con el equipo de la Universidad Normal del Este de China,...","url":"https://www.aioga.com/es/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:43:15.995Z"},"fr":{"title":"L'équipe de l'Université de Pékin a développé le cadre ContactSeek basé sur la probabilité de contact d'AlphaFold3, permettant l'édition précise des bases.","summary":"L'équipe dirigée par Yi Chengqi de l'Institut des sciences de la vie de l'Université de Pékin, en collaboration avec l'équipe de l'Université normale de l'Est de la Chine, a publié un article dans « Nature », proposant le cadre AI ContactSeek basé sur la probabilité de contact (CP) d'AlphaFold3. Ce cadre intègre les CP prédites par AlphaFold3 avec des données d'édition hors cible à haut rendement, identifie systématiquement les résidus aminoacides clés dans les protéines Cas et les désaminases qui déterminent la spécificité de l'édition, et permet de concevoir et modifier des outils d'édition de bases en conséquence. L'étude a identifié une série de nouveaux variants de Cas9 pouvant améliorer la précision de l'ABE, réduisant l'édition hors cible de l'ADN tout en maintenant une édition efficace sur cible.","category":"Recherche","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"L'équipe de l'Université de Pékin a développé le cadre ContactSeek basé sur la probabilité de contact d'AlphaFold3, permettant l'édition précise des bases. - Aioga Actualités IA","description":"L'équipe dirigée par Yi Chengqi de l'Institut des sciences de la vie de l'Université de Pékin, en collaboration avec l'équipe de l'Université normale de l'Est de la Chine, a publié...","url":"https://www.aioga.com/fr/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:44:08.033Z"},"de":{"title":"Ein Team der Peking-Universität entwickelte basierend auf der Kontaktwahrscheinlichkeit von AlphaFold3 das ContactSeek-Framework, um präzises Basenediting zu ermöglichen","summary":"Das Forschungsteam von Yi Chengqi an der Fakultät für Lebenswissenschaften der Peking-Universität in Zusammenarbeit mit dem Team der Ostchina Normal University veröffentlichte einen Artikel in „Nature“ und stellte das auf AlphaFold3-Kontaktwahrscheinlichkeit (CP) basierende KI-Framework ContactSeek vor. Dieses Framework integriert die von AlphaFold3 vorhergesagten CPs mit Hochdurchsatz-Daten zu Off-Target-Editierungen, identifiziert systematisch die entscheidenden Aminosäurereste in Cas-Proteinen und Desaminasen, die die Editierspezifität bestimmen, und nutzt diese Erkenntnisse zur ingenieurmäßigen Weiterentwicklung von Basen-Editierwerkzeugen. Die Studie identifizierte eine Reihe neuer Cas9-Varianten, die die Präzision von ABE verbessern und gleichzeitig die effiziente zielgerichtete Editierung beibehalten und DNA-Off-Target-Editierungen reduzieren.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Ein Team der Peking-Universität entwickelte basierend auf der Kontaktwahrscheinlichkeit von AlphaFold3 das ContactSeek-Framework, um präzises Basenediting zu ermöglichen - Aioga KI-News","description":"Das Forschungsteam von Yi Chengqi an der Fakultät für Lebenswissenschaften der Peking-Universität in Zusammenarbeit mit dem Team der Ostchina Normal University veröffentlichte eine...","url":"https://www.aioga.com/de/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:44:09.689Z"},"pt-BR":{"title":"A equipe da Peking University desenvolveu o framework ContactSeek com base na probabilidade de contato do AlphaFold3, capacitando a edição precisa de bases","summary":"O grupo de pesquisa de Yicheng Qi da Faculdade de Ciências da Vida da Universidade de Pequim, em colaboração com a equipe da Universidade Normal do Leste da China, publicou um artigo na revista Nature, propondo o framework de IA ContactSeek, baseado na probabilidade de contato (CP) do AlphaFold3. Esse framework integra a CP prevista pelo AlphaFold3 com dados de edição fora do alvo de alta vazão, identificando sistematicamente os resíduos de aminoácidos chave que determinam a especificidade de edição em proteínas Cas e desaminases, e com base nisso, realiza a engenharia e modificação de ferramentas de edição de bases. O estudo identificou uma série de novas variantes de Cas9 que podem aumentar a precisão do ABE, mantendo ao mesmo tempo uma edição eficiente no alvo, enquanto reduzem a edição fora do alvo no DNA.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"A equipe da Peking University desenvolveu o framework ContactSeek com base na probabilidade de contato do AlphaFold3, capacitando a edição precisa de bases - Aioga Notícias de IA","description":"O grupo de pesquisa de Yicheng Qi da Faculdade de Ciências da Vida da Universidade de Pequim, em colaboração com a equipe da Universidade Normal do Leste da China, publicou um arti...","url":"https://www.aioga.com/pt-BR/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:44:47.028Z"},"ru":{"title":"Команда Пекинского университета разработала рамочную систему ContactSeek на основе вероятности контакта AlphaFold3, обеспечивая возможность точного редактирования нуклеотидов","summary":"Лаборатория И Чэнци института наук о жизни Пекинского университета совместно с командой Восточно-китайского педагогического университета опубликовала статью в журнале «Nature», предложив AI-фреймворк ContactSeek, основанный на вероятности контакта (CP) AlphaFold3. Этот фреймворк интегрирует CP, предсказанную AlphaFold3, с данными высокопроизводительного офф-таргетного редактирования, системно идентифицируя ключевые аминокислотные остатки в белках Cas и дезаминазах, определяющие специфичность редактирования, и на этой основе инженерно модифицирует инструменты редактирования основанных на основаниях. Исследование выявило серию новых вариантов Cas9, которые могут повысить точность ABE, снижая офф-таргетное редактирование ДНК при сохранении высокой эффективности редактирования на целевом участке.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Команда Пекинского университета разработала рамочную систему ContactSeek на основе вероятности контакта AlphaFold3, обеспечивая возможность точного редактирования нуклеотидов - Aioga Новости ИИ","description":"Лаборатория И Чэнци института наук о жизни Пекинского университета совместно с командой Восточно-китайского педагогического университета опубликовала статью в журнале «Nature», пре...","url":"https://www.aioga.com/ru/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:44:49.237Z"},"ar":{"title":"قام فريق جامعة بكين بتطوير إطار عمل ContactSeek بناءً على احتمال الاتصال في AlphaFold3، لتمكين التحرير الدقيق للقواعد.","summary":"نشر فريق بحث بقيادة إي تشنغي من مختبر علوم الحياة بجامعة بكين بالتعاون مع فريق من جامعة شرق الصين للمعلمين ورقة في مجلة Nature، اقترحوا فيها إطار الذكاء الاصطناعي ContactSeek القائم على احتمال الاتصال (CP) من AlphaFold3. يدمج هذا الإطار CP المتنبأ به بواسطة AlphaFold3 مع بيانات التحرير خارج الهدف عالية الإنتاجية، ويحدد بشكل منهجي البقايا الأمينية الرئيسية في بروتينات Cas والدياميناز التي تحدد خصوصية التحرير، ويستند لذلك إلى تعديل هندسي لأدوات تحرير القواعد. وقد حددت الدراسة سلسلة من متغيرات Cas9 الجديدة التي يمكن أن تزيد من دقة ABE، مع الحفاظ على التحرير الفعال للمواقع المستهدفة وتقليل التحرير خارج الهدف للـ DNA.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"قام فريق جامعة بكين بتطوير إطار عمل ContactSeek بناءً على احتمال الاتصال في AlphaFold3، لتمكين التحرير الدقيق للقواعد. - Aioga أخبار الذكاء الاصطناعي","description":"نشر فريق بحث بقيادة إي تشنغي من مختبر علوم الحياة بجامعة بكين بالتعاون مع فريق من جامعة شرق الصين للمعلمين ورقة في مجلة Nature، اقترحوا فيها إطار الذكاء الاصطناعي ContactSeek القائ...","url":"https://www.aioga.com/ar/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:45:33.628Z"},"hi":{"title":"बीजिंग विश्वविद्यालय की टीम ने AlphaFold3 की संपर्क संभावना पर आधारित ContactSeek फ्रेमवर्क विकसित किया, जो सटीक बेस संपादन को सक्षम बनाता है","summary":"बीजिंग विश्वविद्यालय जीवन विज्ञान संस्थान की यी चेंगकी रिसर्च टीम ने हुआडॉन्ग शिक्षक विश्वविद्यालय की टीम के साथ मिलकर 《नेचर》 में एक पेपर प्रकाशित किया, जिसमें AlphaFold3 संपर्क संभावना (CP) पर आधारित AI फ्रेमवर्क ContactSeek का प्रस्ताव रखा गया। इस फ्रेमवर्क ने AlphaFold3 द्वारा भविष्यवाणी की गई CP और उच्च-थ्रूपुट ऑफ-टार्गेट संपादन डेटा को एकीकृत किया, जिससे Cas प्रोटीन और डैमिनेस में एडिटिंग विशिष्टता को निर्धारित करने वाले प्रमुख अमीनो एसिड अवशेषों की प्रणालीगत पहचान हुई, और इसके आधार पर बेस संपादन टूल्स को इंजीनियरिंग संशोधित किया गया। अध्ययन ने कई नए Cas9 वेरिएंट्स की पहचान की, जो ABE की सटीकता बढ़ा सकते हैं, लक्ष्य पर उच्च प्रभावी संपादन बनाए रखते हुए DNA ऑफ-टार्गेट संपादन को कम करते हैं।","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"बीजिंग विश्वविद्यालय की टीम ने AlphaFold3 की संपर्क संभावना पर आधारित ContactSeek फ्रेमवर्क विकसित किया, जो सटीक बेस संपादन को सक्षम बनाता है - Aioga AI समाचार","description":"बीजिंग विश्वविद्यालय जीवन विज्ञान संस्थान की यी चेंगकी रिसर्च टीम ने हुआडॉन्ग शिक्षक विश्वविद्यालय की टीम के साथ मिलकर 《नेचर》 में एक पेपर प्रकाशित किया, जिसमें AlphaFold3 संपर्क सं...","url":"https://www.aioga.com/hi/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:45:33.889Z"},"it":{"title":"Il team dell'Università di Pechino ha sviluppato il framework ContactSeek basato sulla probabilità di contatto di AlphaFold3, potenziando l'editing preciso delle basi","summary":"Il gruppo di ricerca di Yi Chengqi dell'Accademia delle Scienze della Vita dell'Università di Pechino, in collaborazione con il team della East China Normal University, ha pubblicato un articolo su \"Nature\", proponendo il framework AI ContactSeek basato sulla probabilità di contatto (CP) di AlphaFold3. Questo framework integra la CP prevista da AlphaFold3 con dati di editing off-target ad alta produttività, identificando sistematicamente i residui aminoacidici chiave nelle proteine Cas e nelle deaminasi che determinano la specificità dell'editing, e sulla base di ciò ingegnerizza strumenti di editing delle basi. Lo studio ha identificato una serie di nuovi varianti di Cas9 in grado di migliorare la precisione degli ABE, mantenendo un editing efficiente sul target e riducendo l'editing off-target del DNA.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Il team dell'Università di Pechino ha sviluppato il framework ContactSeek basato sulla probabilità di contatto di AlphaFold3, potenziando l'editing preciso delle basi - Aioga Notizie IA","description":"Il gruppo di ricerca di Yi Chengqi dell'Accademia delle Scienze della Vita dell'Università di Pechino, in collaborazione con il team della East China Normal University, ha pubblica...","url":"https://www.aioga.com/it/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:46:16.049Z"},"nl":{"title":"Het team van Peking University heeft op basis van AlphaFold3 een ContactSeek-framework ontwikkeld dat kans op contact gebruikt, waarmee nauwkeurige basenbewerking wordt mogelijk gemaakt","summary":"Het laboratorium van Yi Chengqi van de School voor Levenswetenschappen aan de Universiteit van Peking, in samenwerking met het team van East China Normal University, heeft een artikel gepubliceerd in 'Nature', waarin het AI-framework ContactSeek wordt voorgesteld, gebaseerd op AlphaFold3-contactkansen (CP). Dit framework integreert door AlphaFold3 voorspelde CP met hoogdoorvoer off-target bewerkingsgegevens, identificeert systematisch de sleutelaminozuren in Cas-eiwitten en deaminases die bepalen de bewerkingsspecificiteit, en gebruikt deze informatie om base-editing tools te ontwerpen en te verbeteren. Het onderzoek identificeerde een reeks nieuwe Cas9-varianten die de precisie van ABE verhogen, terwijl ze een efficiënte target-bewerking behouden en off-target DNA-bewerking verminderen.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Het team van Peking University heeft op basis van AlphaFold3 een ContactSeek-framework ontwikkeld dat kans op contact gebruikt, waarmee nauwkeurige basenbewerking wordt mogelijk gemaakt - Aioga AI-nieuws","description":"Het laboratorium van Yi Chengqi van de School voor Levenswetenschappen aan de Universiteit van Peking, in samenwerking met het team van East China Normal University, heeft een arti...","url":"https://www.aioga.com/nl/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:46:15.670Z"},"tr":{"title":"Pekin Üniversitesi ekibi, AlphaFold3 temas olasılığına dayalı olarak ContactSeek çerçevesini geliştirerek hassas baz düzenlemeyi mümkün kılıyor","summary":"Pekin Üniversitesi Yaşam Bilimleri Fakültesi Yichengqi Araştırma Grubu, Doğu Çin Normal Üniversitesi ekibiyle ortaklaşa, Nature dergisinde bir makale yayımlayarak, AlphaFold3 temas olasılığına (CP) dayalı AI çerçevesi ContactSeek'i önerdi. Bu çerçeve, AlphaFold3 tarafından tahmin edilen CP ile yüksek verimli of-target düzenleme verilerini entegre ederek, Cas proteinleri ve deaminazlarda düzenleme özgüllüğünü belirleyen kritik amino asit kalıntılarını sistematik olarak tanımlar ve buna dayanarak baz düzenleme araçlarını mühendislik yoluyla geliştirir. Çalışma, yüksek hedefe yönelik düzenlemeyi sürdürürken DNA'nın off-target düzenlemesini azaltan ve ABE hassasiyetini artırabilen bir dizi yeni Cas9 varyantını belirledi.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Pekin Üniversitesi ekibi, AlphaFold3 temas olasılığına dayalı olarak ContactSeek çerçevesini geliştirerek hassas baz düzenlemeyi mümkün kılıyor - Aioga AI Haberleri","description":"Pekin Üniversitesi Yaşam Bilimleri Fakültesi Yichengqi Araştırma Grubu, Doğu Çin Normal Üniversitesi ekibiyle ortaklaşa, Nature dergisinde bir makale yayımlayarak, AlphaFold3 temas...","url":"https://www.aioga.com/tr/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:47:04.660Z"},"vi":{"title":"Nhóm Đại học Bắc Kinh phát triển khung ContactSeek dựa trên xác suất tiếp xúc của AlphaFold3, hỗ trợ chỉnh sửa bazơ chính xác","summary":"Nhóm nghiên cứu của Viện Khoa học Sinh học, Đại học Bắc Kinh do Dịch Thành Khí dẫn đầu phối hợp với đội ngũ từ Đại học Sư phạm Hoa Đông đã công bố bài báo trên tạp chí 《Nature》, đề xuất khung AI ContactSeek dựa trên xác suất tiếp xúc (CP) của AlphaFold3. Khung này tích hợp CP do AlphaFold3 dự đoán với dữ liệu chỉnh sửa ngoài mục tiêu cao thông lượng, hệ thống nhận diện các axit amin quan trọng quyết định đặc hiệu chỉnh sửa trong protein Cas và deaminase, từ đó thiết kế kỹ thuật tái cơ cấu công cụ chỉnh sửa cơ sở. Nghiên cứu đã xác định một loạt biến thể Cas9 mới có thể nâng cao độ chính xác của ABE, trong khi vẫn duy trì hiệu quả chỉnh sửa mục tiêu cao và giảm thiểu chỉnh sửa DNA ngoài mục tiêu.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Nhóm Đại học Bắc Kinh phát triển khung ContactSeek dựa trên xác suất tiếp xúc của AlphaFold3, hỗ trợ chỉnh sửa bazơ chính xác - Tin tức AI Aioga","description":"Nhóm nghiên cứu của Viện Khoa học Sinh học, Đại học Bắc Kinh do Dịch Thành Khí dẫn đầu phối hợp với đội ngũ từ Đại học Sư phạm Hoa Đông đã công bố bài báo trên tạp chí 《Nature》, đề...","url":"https://www.aioga.com/vi/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:47:03.722Z"},"id":{"title":"Tim Peking University mengembangkan kerangka ContactSeek berdasarkan probabilitas kontak AlphaFold3, memberdayakan pengeditan basa yang presisi","summary":"Kelompok penelitian Yi Chengqi dari Sekolah Ilmu Hayati Universitas Peking bekerja sama dengan tim dari Universitas Normal Timur Tiongkok, menerbitkan makalah di 《Nature》, mengajukan kerangka AI ContactSeek berdasarkan probabilitas kontak (CP) AlphaFold3. Kerangka ini mengintegrasikan CP yang diprediksi oleh AlphaFold3 dengan data pengeditan off-target throughput tinggi, secara sistematis mengidentifikasi residu asam amino kunci pada protein Cas dan deaminase yang menentukan spesifisitas pengeditan, dan berdasarkan itu merekayasa alat pengeditan basa. Penelitian ini mengidentifikasi serangkaian varian Cas9 baru yang dapat meningkatkan presisi ABE, sambil mempertahankan pengeditan on-target yang efisien dan mengurangi pengeditan DNA off-target.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Tim Peking University mengembangkan kerangka ContactSeek berdasarkan probabilitas kontak AlphaFold3, memberdayakan pengeditan basa yang presisi - Berita AI Aioga","description":"Kelompok penelitian Yi Chengqi dari Sekolah Ilmu Hayati Universitas Peking bekerja sama dengan tim dari Universitas Normal Timur Tiongkok, menerbitkan makalah di 《Nature》, mengajuk...","url":"https://www.aioga.com/id/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:47:43.321Z"},"th":{"title":"ทีมงานของมหาวิทยาลัยปักกิ่งพัฒนากรอบ ContactSeek บนพื้นฐานของความน่าจะเป็นการสัมผัสของ AlphaFold3 เพื่อเพิ่มศักยภาพในการแก้ไขเบสอย่างแม่นยำ","summary":"กลุ่มวิจัย Yi Chengqi จากวิทยาลัยวิทยาศาสตร์ชีวิต มหาวิทยาลัยปักกิ่งร่วมกับทีมจากมหาวิทยาลัยครูตะวันออกจีน ได้ตีพิมพ์บทความในวารสาร Nature เสนอกรอบ AI ContactSeek ซึ่งอิงตามความน่าจะเป็นการสัมผัส (CP) ของ AlphaFold3 กรอบนี้รวม CP ที่คาดการณ์โดย AlphaFold3 กับข้อมูลการตัดต่อที่ไม่ตรงเป้าหมายในปริมาณสูง เพื่อระบุอย่างเป็นระบบกรดอะมิโนที่สำคัญในโปรตีน Cas และ deaminase ที่กำหนดความเฉพาะของการตัดต่อ และใช้ข้อมูลนี้ปรับปรุงเครื่องมือแก้ไขฐานการตัดต่อ การวิจัยระบุชุดของตัวแปร Cas9 ใหม่ที่สามารถเพิ่มความแม่นยำของ ABE ในขณะที่ยังคงประสิทธิภาพการตัดต่อที่ตรงเป้าหมายและลดการตัดต่อ DNA ที่ไม่ตรงเป้าหมาย","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"ทีมงานของมหาวิทยาลัยปักกิ่งพัฒนากรอบ ContactSeek บนพื้นฐานของความน่าจะเป็นการสัมผัสของ AlphaFold3 เพื่อเพิ่มศักยภาพในการแก้ไขเบสอย่างแม่นยำ - ข่าว AI Aioga","description":"กลุ่มวิจัย Yi Chengqi จากวิทยาลัยวิทยาศาสตร์ชีวิต มหาวิทยาลัยปักกิ่งร่วมกับทีมจากมหาวิทยาลัยครูตะวันออกจีน ได้ตีพิมพ์บทความในวารสาร Nature เสนอกรอบ AI ContactSeek ซึ่งอิงตามความน่า...","url":"https://www.aioga.com/th/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:47:51.186Z"},"pl":{"title":"Zespół z Uniwersytetu Pekińskiego opracował ramy ContactSeek oparte na prawdopodobieństwie kontaktu AlphaFold3, umożliwiając precyzyjną edycję zasad","summary":"Zespół badawczy pod kierownictwem Yi Chengqi z Wydziału Nauk o Życiu Uniwersytetu Pekińskiego we współpracy z zespołem Wschodniego Uniwersytetu Nauczycielskiego opublikował artykuł w czasopiśmie \"Nature\", w którym zaproponowano ramy AI o nazwie ContactSeek oparte na prawdopodobieństwie kontaktu (CP) AlphaFold3. Te ramy integrują CP przewidywane przez AlphaFold3 z danymi o modyfikacjach poza celem w wysokoprzepustowym formacie, systematycznie identyfikując kluczowe reszty aminokwasowe w białkach Cas i deaminazach decydujące o specyfice edycji, a na tej podstawie inżynieryjnie modyfikując narzędzia do edycji nukleotydów. Badanie zidentyfikowało szereg nowych wariantów Cas9, które mogą zwiększyć precyzję ABE, jednocześnie utrzymując wysoką wydajność edycji docelowej i redukując modyfikacje DNA poza celem.","category":"论文研究","source":"IT之家（RSS）","aggregationSource":"IT之家（RSS）","pageTitle":"Zespół z Uniwersytetu Pekińskiego opracował ramy ContactSeek oparte na prawdopodobieństwie kontaktu AlphaFold3, umożliwiając precyzyjną edycję zasad - Aioga Wiadomości AI","description":"Zespół badawczy pod kierownictwem Yi Chengqi z Wydziału Nauk o Życiu Uniwersytetu Pekińskiego we współpracy z zespołem Wschodniego Uniwersytetu Nauczycielskiego opublikował artykuł...","url":"https://www.aioga.com/pl/news/cmrzy9tm101zxrop1a26o2tng/","contentTranslated":true,"sourceHash":"8c328eb4ee41dcdc","translatedAt":"2026-07-28T03:48:36.487Z"}}}}